Erythrocytes and Erythropoietin

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Erythrocytes and Erythropoietin

1Department of Physiology, University of Tübingen, Gmelinstraβe 5, 72076 Tübingen, Germany 2 Institute for Molecular Cell Biology, School of Medicine, Saarland University, 66421 Homburg/Saar, Germany 3 Section of Cell Degeneration and Gender Medicine, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy 4 Institute ...

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Injections of recombinant human erythropoietin increases lactate influx into erythrocytes.

Previous studies showed that erythropoietin not only increases erythrocyte production but is also essential in both the synthesis and the good functioning of several erythrocyte membrane proteins, including band 3. It is still unknown whether anion and/or H(+) fluxes are modified by erythropoietin. This study aimed to evaluate the effect of recombinant human erythropoietin (rHuEPO) injections o...

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Erythropoietin activates nitric oxide synthase in murine erythrocytes.

Erythropoietin (Epo) is the main regulator of erythrocyte production and a potent cytoprotective factor. It was suggested that some of Epo cytoprotective properties are due to its regulation of nitric oxide (NO) production. Recently, functionally active endothelial type NO synthase (eNOS) was discovered in mature murine and human red blood cells (RBC-eNOS). The goal of the present study was to ...

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ERYTHROCYTES A STUDY OF THE ERYTHROPOIETIN CON - rENT OF PLASMA AND URINE IN

S 925 mined by labeling in vitro with 51Cr or in vivo with 32DFP. Eight to ten days later, hyperthermia was created by injection of pyrogen or milk or by external heating in a climate chamber. The hyperthermia was maintained for five consecutive days. During this febrile period definite anemia developed. The red cell survival data strongly suggest that this was due to hemolysis. Arguments are p...

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Enhanced susceptibility to suicidal death of erythrocytes from transgenic mice overexpressing erythropoietin.

Eryptosis, a suicidal death of mature erythrocytes, is characterized by decrease of cell volume, cell membrane blebbing, and breakdown of cell membrane asymmetry with phosphatidylserine exposure at the cell surface. Triggers of eryptosis include increased cytosolic Ca(2+) activity, which could result from activation of Ca(2+)-permeable cation channels. Ca(2+) triggers phosphatidylserine exposur...

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ژورنال

عنوان ژورنال: International Journal of Cell Biology

سال: 2011

ISSN: 1687-8876,1687-8884

DOI: 10.1155/2011/972536